Kobayakawa Sena is a little guy who always get picked on by the bullies in school. Since elementary school, he always play the role of the 'errand boy' to the extent that he has become swift and fast in his movements. Coincidentally, Hiruma Youichi and Kurita Ryukan are looking for a fast running back for their American Football team (Amefuto) and want to put Sena in the team. To hide their new 'star' player from the eyes of other High Schools, Hiruma encases Sena in a Amefuto helmet with a dark visor and name him Eyeshield #21.

Eyeshield 21: Box 1 Episode List:

• 1. The man possessing speed of light legs
  
• 2. Let's play American Football!
  
• 3. Subdue the Field
  
• 4. What's Grasped by Those Hands
  
• 5. Body Guard for 0.5 Seconds
  
• 6. Detonation! Spear Tackle
  
• 7. Fight for Victory
  
• 8. Do not give up!
  
• 9. Expert of Catch
  
• 10. Requirements of a Hero
  
• 11. The Oath under the Setting Sun
  
• 12. Catch! Max!!
  
• 13. Fear of the Cameleon
  
• 14. The Scorching Hell Tower
  
• 15. Find Eyeshield!
  
• 16. Goodbye, Kurita!?
  
• 17. Kid and Iron Horse
  
• 18. Pride of the Useless
  
• 19. The Citizens laugh at the Challenger
  
• 20. Sphinx's Secret Weapon
  
• 21. Fly! Devil Bat
  
• 22. Appearance of the Mysterious Girl
  
• 23. The Weightless Man
  
• 24. Flash! The Nichimei Match
  
• 25. Black Leopard in the Cage
  
• 26. Wild Real
  
• 27. Get Back! Cerberos
  
• 28. American Football, Downtown
  
• 29. Formation, Devil Gunmans!
  
• 30. The Boundary to Hell
  
• 31. Each and Everyone's Determination
  
• 32. Is the scaredy dog around?
  
• 33. Oh! My Sister!
  
• 34. Ghost's Movement
  
• 35. The Solitary Death March
  
• 36. Last Obstacle
  
• 37. The Unreachable Summit
  
• 38. Decision on Regular !?
  
• 39. Road to Christmas Bowl
  
• 40. Night before the Match!
  
• 41. Ace Elimination!?
  
• 42. Devil Bat Ghost!!
  
• 43. The Legendary 60-Yard Magnum44. Ahaha! My Debut!!
  
• 44. Ahaha! My Debut!!
  
• 45. The Ghost is Sealed!?
  
• 46. Ghost vs Spear
  
• 47. It's Hot! Guts!!
  
• 48. Try Hard! Will-power! Do the Best!
  
• 49. Dazzling Silver, Spirit of Line!
  
• 50. Courage not to Escape!
  
• 51. Danger! The Lethal Cameleon
  
• 52. Clash! Cameleon vs Poseidon
  
• 53. Fear of the Poisonous Scorpion!
  
• 54. The Control Tower which Disappeared
  
• 55. Difference in Physique
  
• 56. Our Small Contract!
  
• 57. Those who know "21"
  
• 58. Devil vs Sea God
  
• 59. The Hidden Ace
  
• 60. Promise on the Field!
  
• 61. Obsession to Win!
  
• 62. Terror! Moby Dick Anchor
  
• 63. Offense and Defence 30 cm!!
  
• 64. The man possessing speed of light appears!?
  
• 65. Deimon High School Sports Meet!!