Kobayakawa Sena is a little guy who always get picked on by the bullies in school. Since elementary school, he always play the role of the 'errand boy' to the extent that he has become swift and fast in his movements. Coincidentally, Hiruma Youichi and Kurita Ryukan are looking for a fast running back for their American Football team (Amefuto) and want to put Sena in the team. To hide their new 'star' player from the eyes of other High Schools, Hiruma encases Sena in a Amefuto helmet with a dark visor and name him Eyeshield #21.

Eyeshield 21: Box 2 Episode List:

• 66. Sprinter Sena!?
• 67. Promise of the Three
• 68. Fastest Proof
• 69. Field of Desperation
• 70. Musashi is here
• 71. The Devil's Counterattack
• 72. Pride of Speed of Light
• 73. Fated Kick
• 74. A Rival's Promise
• 75. Spider's Threat
• 76. Come Back! Musashi!
• 77. The Real "21"
• 78. The one who waits previously
• 79. Kobayakawa Sena
• 80. The Strongest Kick Team
• 81. The truth of red pupil
• 82. Run! Musashi!
• 83. Time that began to move
• 84. The Devil in the Storm
• 85. The man that love by God
• 86. Time Up of the Light and Shadow
• 87. The strongest soldiers in Tokyo!!
• 88. Deimon Half Time Show
• 89. Opening! Cream Puff Cup!!
• 90. Brand New Trial
• 91. Fighting Spirit! Death Climb
• 92. 3 Brothers of Texas Ranch
• 93. Yell of Friendship
• 94. Secret Weapon in Silverly White
• 95. Break down the Wall of Blizzard
• 96. Now! To the Kantou Meet!
• 97. Farewell, Onihei
• 98. Cameleon's Counterattack!
• 99. Deimon High School Festival!!
• 100. The Invisible Lock
• 101. Strongest Evil
• 102. Overcome your Fears
• 103. The Impregnable Defence Doubles Topper
• 104. One Line Lacking