Two brothers lose their mother to an incurable disease. With the power of "alchemy", they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother's soul to a suit of armor. With the help of a family friend, Edward receives metal limbs - "automail" - to replace his lost ones. With that, Edward vows to search for the Philosopher's Stone to return the brothers to their original bodies, even if it means becoming a "State Alchemist", one who uses his/her alchemy for the military.

Fullmetal Alchemist: Brotherhood (TV) Limited Edition: Complete Box Set (DVD) Episode titles:

• 1. Fullmetal Alchemist
  
• 2. The First Day
  
• 3. The Heretic City
  
• 4. An Alchemist's Distress
  
• 5. Rain of Sorrow
  
• 6. The Road of Hope
  
• 7. The Hidden Truth
  
• 8. Research Laboratory 5
  
• 9. Created Feelings
  
• 10. Separate Paths
  
• 11. The Miracle at Rush Valley
  
• 12. One is All, All is One
  
• 13. The Beasts of Dublith
  
• 14. Those Who Lurk Underground
  
• 15. Emissary From the East
  
• 16. The Footsteps of a War Comrade
  
• 17. Cool-Headed Flames
  
• 18. On the Palm of an Arrogant Human Being
  
• 19. The Death of the Undying
  
• 20. The Father Standing Before a Grave
  
• 21. The Fool's Progress
  
• 22. Distant Backs
  
• 23. The Girl in the Battlefield
  
• 24. Within the Stomach
  
• 25. The Door of Darkness
  
• 26. Reunion
  
• 27. Interlude Party
  
• 28. Father
  
• 29. Struggle of the Fool
  
• 30. The Ishbal Annihilation Campaign
  
• 31. The Promise Made For 520 Cenz
  
• 32. The Son of the Führer
  
• 33. The Northern Wall of Briggs
  
• 34. Ice Queen
  
• 35. The Shape of This Country
  
• 36. Family Portrait
  
• 37. The Original Homunculus
  
• 38. Clash in Baschool
  
• 39. Daydream
  
• 40. The Dwarf Inside the Flask
  
• 41. Hell
  
• 42. The Signs of a Counterattack
  
• 43. The Ant's Bite
  
• 44. A Full Recovery
  
• 45. The Promised Day
  
• 46. The Creeping Shadow
  
• 47. Messenger of Darkness
  
• 48. An Oath Made in the Underground
  
• 49. Familial Affection
  
• 50. Upheaval in Central
  
• 51. Army of Immortals
  
• 52. Everyone's Power
  
• 53. The Flames of Revenge
  
• 54. Beyond the Raging Fire
  
• 55. The Adults' Way of Life
  
• 56. The Return of the Führer
  
• 57. Eternal Leave
  
• 58. Sacrifices
  
• 59. Lost Light
  
• 60. Eye of Heaven, Gateway of Earth
  
• 61. Kami o Nomikomishi Mono
  
• 62. The Violent Counterattack
  
• 63. The Other Side of the Gate
  
• 64. The Journey's End